The synthesis of penylurea fungicide,pencycuron

By: Zhang Zhenming, Jia Yonggang, Wang Canming, Gao Shan, Liang Min, Sun Ke

4-Chlorlbenzylamine was prepared by amination of p-chlorobenzylchloride with hexamethylenethylenetetramine.A solution of 4-chlorobenzylamine and cyclopentyltanone were dissolved in ethanol,and were poured in the autoclave, and a mixture was condensed and hydrogenated to give N – 4 –chlorobenzyl - N - cycopentylamine on the catalyst at 3.5kg / cm2 H at 40 centigrade Finally, a toluene solution of N – 4 - chlorobenzyl –N- cycopentylamine was treated with phenylisocyanate, and heated at 50 centigrade for 8h affored pencycuron with 95% purity. The total yield was 67.3% based on the starting material of p-chlorobenzylcblarde.

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