BY： Moheb H. Makary, Joseph C. Street, Raghubir P.
Sharma
The distribution and elimination of dicamba (3,6-dichloro-2-methoxy benzoic
acid) and another isomer present in dicamba formulation (3,5-dichloro-2-methoxy
benzoic acid) were studied in rats following single intravenous injections.
Concentrations of dicamba and the isomer were measured at various times
in whole blood by EC-GLC after extraction and derivatization with diazomethane.
The isomer had different toxicokinetic parameters compared to dicamba. The
elimination of 
dicamba from the blood was rapid with a biological half-life
of 0.64 hr (following 100 mg/kg iv dose) while the elimination of the isomer
from the blood was much slower with a biological half-life of 16.5 hr (following
20 mg/kg iv dose). However, upon combined dosing of the two compounds the
elimination rate constant of dicamba significantly decreased. The isomer had a
greater degree of binding to blood serum proteins than dicamba.Yangzhou pioneer chemical CO.,LTD.
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